Drug Interactions Might Provoke Tenofovir-Associat

Drug Interactions May Provoke Tenofovir-Associated Renal Failure (pr...

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Drug Interactions Might Provoke Tenofovir-Associated Renal Failure
Abigail Zuger, MD post: 03/13/2006; AIDS Clinical Care. 2006;4(2) © 2006 Massachusetts Medical Society

A review of 27 cases suggests that ritonavir, ddI, and atazanavir might raise the risk for tenofovir-associated nephritic failure. Tenofovir seldom causes patients to complain of side effects, and some studies have suggested that it is unbosom of major toxicity. However, its use has been associated with the development of acute, sometimes irreversible, nephritic dysfunction, and risks for this tortuousness are not well understood. Researchers account on 5 new cases of tenofovir-associated renal failure and reviewed 22 cases previously reported in the literature. All 27 patients were receiving tenofovir in a conspiracy antiretroviral regimen that included ritonavir (21 patients), ddI (9 patients), and atazanavir (5 patients). Duration of tenofovir use ranged from 1 to 29 months (mean, 11 months). CD4-cell counts and viral loads ranged widely. All patients had ruler serum creatinine levels at baseline.



Renal failure was accompanied by Fanconi syndrome in 16 patients, proteinuria in 6, and urinary bank deposit characteristic of acute tubular necrosis in 8. deuce patients briefly required dialysis. After tenofovir was discontinued, urinary abnormalities resolved in all patients, although five still had some degree of renal dysfunction after a mean follow-up of 7.5 months. The authors mull that interactions with other antiretrovirals are responsible for sporadic cases of tenofovirassociated renal failure. ritonavir inhibits secretion of tenofovir into the urine and may raise serum tenofovir levels considerably. ddI may compete with tenofovir for urinary secretion, resulting in elevated serum levels of ddI and ddI-associated renal damage. Atazanavir also...If you want to get a full essay, order it on our website: Orderessay



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